), which is identical angular situation given that the covalent connections involving the ChVLig OB domain as well as strands with the latch. Consequently, Character has uncovered really different structural solutions to the condition of DNA envelopment by ATP-dependent ligases.
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). The NTase domain binds to the damaged and intact DNA strands in the most important groove flanking the nick and likewise in the insignificant groove around the 3′-OH aspect from the nick (supplemental Fig. S3). The OB domain binds across the minimal groove on the encounter from the duplex powering the nick.
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